Weathering Signals of Millennial-Scale Oscillations of the East-Asian Summer Monsoon over the Last 220 ka

This study generated a high-resolution paleoweathering record of the loess-soil sequence from the central Loess Plateau covering the last 220 ka using the ratio between the CBD (citrate-bicarbonate-dithionite) extractable free Fe_2O_3 (Fed) and total Fe_2O_3 (Fet). The new proxy shows a series of millennial oscillations, which are not necessarily documented by magnetic susceptibility from the same site. Because chemical weathering in the region depends mainly upon summer precipitation and temperature, we interpret these changes to be a result of millennial-scale variations in the strength of the East-Asian summer monsoon. Over the last glacial period, there is general agreement between the loess weathering record and the GRIP ice δ~(18)O record. The first suggests a rather stable summer monsoon pattern during the Last Interglacial period (marine δ~(18)O stage 5e). Large amplitude millennial oscillations of the summer monsoon seem to be particularly characteristic of the last glacial period whereas the fluctuations for the older periods are smoother.     

Thymidine kinase gene mutation leads to reduced virulence of pseudorabies virus

To explore correlation between the tk gene structure of pseudorabies virus (PRV) and its virulence, to study the effect of the gene mutation on PRV biological properties, and to investigate mechinism of reduced virulence, thymidine kinase (TK)-deficient mutant of pseudorabies virus strain Hubei (PRV HB) was isolated by selection for resistance to 5-bromodeoxyuridine. The tk genes of PRV HB and its TK^― mutant were cloned and sequenced. 1587 base pairs of the tk gene and flanking regions of wild-type (wt) virus were sequenced, which included an open reading frame (ORF) of 1098 bp encoding a protein of 366 amino acids. The ORF contained two 137-bp repeated sequences, which were connected by an adenosine. 1458 bp of the tk and flanking regions of TK^― mutant were sequenced. Analysis of the tk gene sequence of TK^― mutant indicated that one of 137 bp repeated sequence and the connecting adenosine in the tk gene of the wt virus was deleted and a repeated sequence of 8 nucleotides (GCGCGCC) was inserted. All other nucleotides of TK^―mutant were identical to that of wt virus. Deletion and insertion of the nucleotide sequence resulted in a frameshift and a premature chain termination, and the resultant TK protein was not active. Analysis of the amino acid sequence revealed that TK protein of PRV HB contained the conserved consensus sequence of herpesviral TKs and an additional conserved-DHR-motif. The results of this work also indicated that TK^― mutant was genetically stable. Compared to PRV HB, virulence of TK^― mutant was greatly decreased. Mice vaccinated with TK^― mutant were completely protected against a lethal challenge with virulent PRV (HB).     

H2株甲肝减毒活疫苗K7的核苷酸全序列分析

应用ＲＴ－ＰＣＲ获取Ｈ２株甲肝减毒活疫苗（Ｋ７）的ｃＤＮＡ片段，经末端终止测序ＰＣＲ试剂盒和全自动测序仪（ＡＢＩ３７７）作序列测定，用Ｍａｘｔｒｉｇｅｎｅ软件进行计算机分析，Ｋ７疫苗病毒的核苷酸全长含７４４３个碱基．Ｋ７对比其亲代Ｈ２株，减毒的ＨＭ１７５株以及ＨＭ１７５野毒株，同源性分别为９９．７５％，９９．９５％和９９．６１％；彼此间在Ｐ１和Ｐ２连接区１６８个碱基的同源性为９９．４％～１００％，均为ⅠＢ基因亚型．前三者在５’非编码区均有１３１～１３４位和２０３位５个碱基缺失，且结构蛋白基因区序列完全一致．本文用分子病毒学方法证实了Ｋ７疫苗的优异纯毒水平，也为开展甲型肝炎分子流行病学工作提供了基础资料     

利用双谱分析法检测心室纤颤信号

提出了一种基于信号双谱分析的心室纤颤检测方法．首先，根据信号的准周期性，对信号进行了分段，并改进了信号三阶累积量的估计．然后，以特征值Ｐ表征信号，给出了心室纤颤信号的双谱检测算法，并结合其他算法，采取多特征值检测法进一步优化算法的性能．最后，在不同的噪声条件下，对不同的算法进行了比较，给出了微机实验的结果．实验表明：本文提出的心室纤颤检测算法达到了较优的灵敏度及误判率，并具有较强的抗噪声性能     

UIO序列的启发式算法

UIO序列是对有限状态机进行功能测试的有效手段 ,在 VLSI设计、通信协议等时序系统中有很强的实际应用背景。文章基于可区分状态组这一概念设计了一个搜索算法 ,进一步利用搜索信息建立了一个基于“小于”关系的启发策略 ,有效的剪枝策略的设计将尽可能消除没有意义的搜索分枝 ,新设计出的多路 OPEN/CLOSED表存储机制也加快了相关的判别和处理过程。这些措施改进了搜索过程 ,减少了搜索信息的产生 ,提高了搜索速度。该算法与以往的算法相比 ,在时间和空间两方面都得到了很大改进。     

用GAL构成无计数误差的倍频鉴相器

从逻辑和时序上说明了无计数误差四倍频鉴相器的结构，为使此结构满足GAL的“组合逻辑结构”，给出了满足GAL的逻辑方程。     

关于John Beebee的一个问题

回答了John Beebee关于不相交同余覆盖的一个问题。     

矢值序列空间ss(Ek)的正规结构和中点局部一致凸

矢值序列空间ss(Ek)是Banach序列空间lp(Ek)的重要推广.本文讨论了ss(Ek)的正规结构和中点局部一致凸.     

关于p-一致光滑Banach空间中非自映像的Reich公开问题

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重新排序问题的Pareto最优解

为了保证先来顾客的需求和工件本身错位量的要求,着重研究这种使先来顾客的总目标函数值与工件错位量之间达到平衡的问题,即重新排序问题的Pareto最优解问题.对于最大延迟和工件错位量的Pareto最优解问题,给出了这些问题的多项式时间算法或计算复杂度.